Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases

Identifying biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are (EVs) different sizes biological functions transported in blood they may be valid NDs. The aim our study was to investigate common miRNA signatures plasma derived LEVs SEVs Alzheimer’s disease (AD), Parkinson’s (PD), Amyotrophic Lateral Sclerosis (ALS) Fronto-Temporal Dementia (FTD) patients. were isolated from patients healthy volunteers (CTR) by filtration differential centrifugation RNA extracted. Small RNAs libraries carried out Next Generation Sequencing (NGS). MiRNAs discriminate all NDs CTRs can provide a signature each Common enriched pathways instead linked ubiquitin mediated proteolysis Toll-like receptor signaling neurotrophin Glycosphingolipid biosynthesis pathway. involved this might give specificity their role the spreading disease. miRNAs great interest biomarker discovery pathogenesis studies neurodegeneration.